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GLP-1 medications are synthetic versions of this hormone designed to mimic its effects
Radtke, Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
Its onset is driven by obesity, sedentary behavior, and genetic predisposition, leading to insulin resistance, progressive beta-cell dysfunction, and complications such as cardiovascular disease and nonalcoholic fatty liver disease (NAFLD)
For context: 20% weight loss for a 200 lb person = 40 lbs Thats simply not realistic in one month, even with GLPs Truth bomb: While you can lose a significant amount quickly, 2030% body weight loss usually takes 612 months, not 30 days
By increasing autophagy and decreasing inflammation, he believes that rapamycin is doing something similar
Other treatments include: Insulin (glargine, degludec): Strong glucose lowering, but often linked to weight gain
